:root {
  --bg: #ffffff;
  --bg-soft: #fbfaf6;
  --panel: #ffffff;
  --ink: #171816;
  --muted: #62655d;
  --line: rgba(23, 24, 22, 0.12);
  --accent: #0f6a56;
  --accent-soft: rgba(15, 106, 86, 0.08);
  --radius: 8px;
  --mono: "IBM Plex Mono", "SFMono-Regular", Consolas, monospace;
  --sans: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
}

* {
  box-sizing: border-box;
}

html {
  scroll-behavior: smooth;
}

body {
  margin: 0;
  min-height: 100vh;
  color: var(--ink);
  font-family: var(--sans);
  background: var(--bg);
}

img,
video {
  display: block;
  width: 100%;
  border: 0;
}

a {
  color: inherit;
}

.page-shell {
  width: min(1180px, calc(100% - 2rem));
  margin: 0 auto;
  padding: 2rem 0 4rem;
}

.hero {
  display: grid;
  gap: 1rem;
  padding: 1.5rem 0 1.2rem;
}

.section-kicker,
.dataset-chip,
.media-label {
  font-family: var(--mono);
  font-size: 0.72rem;
  letter-spacing: 0.14em;
  text-transform: uppercase;
}

.section-kicker,
.media-label {
  color: var(--accent);
}

.hero-copy {
  max-width: 48rem;
}

.hero h1,
.intro-head h2,
.dataset-heading h2 {
  margin: 0;
  font-weight: 600;
  letter-spacing: 0;
}

.hero h1 {
  font-size: clamp(2.8rem, 8vw, 5.4rem);
  line-height: 0.95;
}

.hero-text,
.intro-body p,
.dataset-heading p,
.media-caption {
  margin: 0;
  color: var(--muted);
  line-height: 1.65;
  font-size: 0.95rem;
}

.hero-text {
  margin-top: 1rem;
  font-size: 0.98rem;
}

.authors {
  display: grid;
  gap: 0.25rem;
  margin-top: 1.35rem;
  color: var(--muted);
  font-size: 0.9rem;
  line-height: 1.45;
}

.authors a {
  color: var(--ink);
  text-decoration-color: rgba(23, 24, 22, 0.22);
  text-underline-offset: 0.2em;
}

.authors a:hover,
.authors a:focus-visible {
  color: var(--accent);
  outline: none;
}

.code-link {
  display: inline-flex;
  align-items: center;
  gap: 0.55rem;
  padding: 0.55rem 0.55rem;
  border: 1px solid var(--line);
  border-radius: 4px;
  background: var(--bg-soft);
  color: var(--ink);
  text-decoration: none;
  font-family: var(--mono);
  font-size: 0.8rem;
}

.code-link:hover,
.code-link:focus-visible {
  border-color: var(--accent);
  color: var(--accent);
  outline: none;
}

.authors-names {
  margin: 0 0 0.35rem;
}

.affil {
  color: var(--muted);
  font-size: 0.9em;
  margin-left: 0.15rem;
  vertical-align: super;
}

.institution {
  margin: 0.25rem 0 0;
}

.institution a {
  color: var(--muted);
}

.institution a:hover,
.institution a:focus-visible {
  color: var(--accent);
}

.external-links {
  display: flex;
  flex-wrap: wrap;
  gap: 0.55rem;
  margin: 1.5rem 0 0 0;
}

.intro-panel,
.dataset {
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: var(--bg-soft);
}

.intro-panel {
  display: grid;
  gap: 1rem;
  padding: 0.6rem 1.5rem 1.5rem;
}

.intro-body {
  display: grid;
  gap: 0.8rem;
}

.intro-steps {
  display: grid;
  gap: 0.45rem;
  margin: 0;
  padding-left: 1.25rem;
  color: var(--muted);
  font-size: 0.95rem;
  line-height: 1.55;
}

.dataset-nav {
  display: grid;
  gap: 0.5rem;
  margin: 1.25rem 0 1.5rem;
  padding: 0.8rem;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: var(--panel);
  max-width: 24rem;
}

.dataset-chip {
  padding: 0.5rem 0.65rem;
  border: 1px solid var(--line);
  border-radius: 6px;
  background: rgba(255, 255, 255, 0.65);
  text-decoration: none;
}

.dataset-chip:hover,
.dataset-chip:focus-visible {
  border-color: rgba(15, 106, 86, 0.28);
  background: var(--accent-soft);
  outline: none;
}

.datasets {
  display: grid;
  gap: 1.5rem;
}

.dataset {
  padding: 1.5rem;
}

.dataset-heading {
  display: grid;
  gap: 0.65rem;
  padding-bottom: 1.25rem;
  border-bottom: 1px solid var(--line);
}

.dataset-heading h2 {
  font-size: clamp(1.45rem, 4vw, 2.05rem);
}

.citation-link {
  color: var(--accent);
  text-decoration-color: rgba(15, 106, 86, 0.35);
  text-underline-offset: 0.18em;
}

.citation-link:hover,
.citation-link:focus-visible {
  text-decoration-color: currentColor;
  outline: none;
}

.plot-embed {
  overflow: hidden;
  margin-top: 1.5rem;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: #fff;
}

.plot-embed iframe {
  display: block;
  width: 100%;
  height: min(82vh, 54rem);
  border: 0;
}

.media-note {
  margin: 1rem 0 0;
  color: var(--muted);
  font-size: 0.82rem;
}

.dataset-subsections {
  display: grid;
  gap: 1.7rem;
  margin-top: 1.5rem;
}

.dataset-subsection {
  display: grid;
  gap: 1.2rem;
  padding-top: 1.45rem;
  border-top: 1px solid var(--line);
}

.dataset-subsection:first-child {
  padding-top: 0;
  border-top: 0;
}

.dataset-subsection h3 {
  margin: 0;
  color: var(--text);
  font-size: 1.05rem;
  font-weight: 600;
}

.dataset-subsection .plot-embed,
.dataset-subsection .comparison-list {
  margin-top: 0;
}

.comparison-list {
  display: grid;
  gap: 1.5rem;
  margin-top: 1.5rem;
}

.comparison-row {
  display: grid;
  gap: 0.75rem;
}

.comparison-media {
  display: grid;
  grid-template-columns: minmax(0, 1fr) minmax(0, 1fr);
  gap: 1rem;
}

.dataset-small .comparison-media {
  max-width: 680px;
  margin-inline: auto;
}

.comparison-media:has(.media-card-image) {
  max-width: none;
  grid-template-columns: minmax(0, 1fr) minmax(18rem, 330px);
}

.comparison-media:has(.media-card-image) .media-card-video {
  justify-self: center;
  width: 100%;
  max-width: 330px;
}

.dataset-large .comparison-media {
  max-width: none;
}

.media-card {
  display: grid;
  gap: 0.75rem;
  padding: 0.9rem;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: #fff;
}

.media-shell {
  position: relative;
  display: flex;
  align-items: center;
  justify-content: center;
  overflow: hidden;
  border-radius: 6px;
  background: #fff;
}

.media-card-image .media-shell {
  background: #fff;
}

.video-frame,
.zoom-video-frame {
  position: relative;
  display: inline-flex;
  line-height: 0;
  max-width: 100%;
}

.patch-grid {
  position: absolute;
  inset: 0;
  z-index: 1;
  width: 100%;
  height: 100%;
  pointer-events: none;
}

.patch-grid rect,
.patch-grid line {
  fill: none;
  stroke: rgba(246, 248, 242, 0.4);
  stroke-width: 1px;
  stroke-dasharray: 1px 6px;
  stroke-linecap: round;
  vector-effect: non-scaling-stroke;
}

.image-zoom-trigger {
  display: block;
  width: 100%;
  padding: 0;
  border: 0;
  background: transparent;
  cursor: zoom-in;
}

.video-zoom-trigger {
  position: absolute;
  top: 0.55rem;
  right: 0.55rem;
  padding: 0.28rem 0.45rem;
  border: 1px solid rgba(255, 255, 255, 0.32);
  border-radius: 6px;
  background: rgba(20, 20, 20, 0.28);
  color: rgba(255, 255, 255, 0.78);
  font-family: var(--mono);
  font-size: 0.65rem;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  cursor: zoom-in;
}

.video-zoom-trigger:hover,
.video-zoom-trigger:focus-visible {
  background: rgba(20, 20, 20, 0.48);
  color: #fff;
  outline: none;
}

.media-label-row {
  display: flex;
  align-items: center;
  gap: 0.45rem;
  min-height: 1.15rem;
}

.video-state-toggle {
  display: inline-grid;
  place-items: center;
  width: 1.05rem;
  height: 1.05rem;
  padding: 0;
  border: 1px solid rgba(15, 106, 86, 0.35);
  border-radius: 999px;
  background: transparent;
  color: var(--accent);
  cursor: pointer;
}

.video-state-toggle:focus-visible {
  outline: 2px solid rgba(15, 106, 86, 0.35);
  outline-offset: 2px;
}

.video-state-toggle[data-video-state="playing"] {
  animation: video-state-pulse 1.45s ease-in-out infinite;
}

.video-state-icon {
  position: relative;
  display: block;
  width: 0.46rem;
  height: 0.52rem;
}

.video-state-play {
  position: absolute;
  top: 0;
  left: 0.08rem;
  width: 0;
  height: 0;
  border-top: 0.26rem solid transparent;
  border-bottom: 0.26rem solid transparent;
  border-left: 0.38rem solid currentColor;
}

.video-state-pause {
  position: absolute;
  inset: 0;
  display: none;
}

.video-state-pause::before,
.video-state-pause::after {
  content: "";
  position: absolute;
  top: 0.02rem;
  width: 0.13rem;
  height: 0.48rem;
  border-radius: 999px;
  background: currentColor;
}

.video-state-pause::before {
  left: 0.07rem;
}

.video-state-pause::after {
  right: 0.07rem;
}

.video-state-toggle[data-video-state="playing"] .video-state-play {
  display: none;
}

.video-state-toggle[data-video-state="playing"] .video-state-pause {
  display: block;
}

@keyframes video-state-pulse {
  0%,
  100% {
    box-shadow: 0 0 0 0 rgba(15, 106, 86, 0.18);
  }

  50% {
    box-shadow: 0 0 0 0.22rem rgba(15, 106, 86, 0);
  }
}

@media (prefers-reduced-motion: reduce) {
  .video-state-toggle[data-video-state="playing"] {
    animation: none;
  }
}

.media-shell img,
.media-shell video {
  display: block;
  max-height: 18rem;
  object-fit: contain;
  background: transparent;
}

.media-shell img {
  background: #fff;
}

.dataset-small .media-card-image .media-shell img {
  width: 100%;
  max-height: 34rem;
}

.series-labels {
  display: grid;
  grid-template-columns: repeat(var(--series-count), minmax(0, 1fr));
  gap: 0.35rem;
  color: var(--muted);
  font-family: var(--mono);
  font-size: 0.68rem;
  line-height: 1.2;
  text-align: center;
}

.series-labels span {
  min-width: 0;
  overflow-wrap: anywhere;
}

.dataset-large .media-shell img,
.dataset-large .media-shell video {
  max-height: 42rem;
}

#cell-cycle .media-shell img,
#cell-cycle .media-shell video {
  max-height: 40rem !important;
  min-width: 18rem !important;
}

#cell-cycle .media-card-image .media-shell {
  justify-content: center;
}

#cell-cycle .media-card-image {
  padding: 0.45rem;
}

#cell-cycle .media-card-image .media-shell img {
  width: 100%;
  max-width: 1348px;
}

#nash-steatosis .media-card-video .media-shell video {
  width: 18rem;
  max-width: 100%;
}

.media-label {
  margin: 0;
}

.image-zoom-dialog {
  width: fit-content;
  max-width: calc(100vw - 2rem);
  max-height: calc(100vh - 2rem);
  padding: 1rem;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: #fff;
  overflow: visible;
}

.image-zoom-dialog::backdrop {
  background: rgba(25, 26, 22, 0.48);
}

.image-zoom-dialog [hidden] {
  display: none !important;
}

.image-zoom-dialog img,
.image-zoom-dialog video {
  display: block;
  max-width: calc(100vw - 4rem);
  max-height: 84vh;
  object-fit: contain;
}

.image-zoom-dialog .zoom-video-frame {
  margin-inline: auto;
}

.image-zoom-dialog img {
  width: min(92vw, 1200px);
}

.image-zoom-dialog video {
  width: min(58vw, 560px);
  max-height: 54vh;
  margin-inline: auto;
  background: transparent;
}

.image-zoom-dialog[data-zoom-mode="large"] video {
  width: min(78vw, 880px);
  max-height: 68vh;
}

.zoom-series-labels {
  margin-top: 0.75rem;
}

.zoom-title {
  margin: 0 0 0.75rem;
}

.image-zoom-close {
  display: block;
  margin: 0 0 0.75rem auto;
  border: 1px solid var(--line);
  border-radius: 6px;
  background: var(--panel);
  color: var(--text);
  font: inherit;
  cursor: pointer;
}

.empty-note {
  padding: 1rem;
  border: 1px dashed var(--line);
  border-radius: 1rem;
  color: var(--muted);
}

.noscript-note {
  width: min(1120px, calc(100% - 2rem));
  margin: 0 auto 2rem;
  padding: 1rem;
  border: 1px solid var(--line);
  border-radius: 1rem;
  background: #fff9ef;
  color: var(--muted);
  font-family: var(--mono);
  font-size: 0.85rem;
}

@media (max-width: 960px) {
  .comparison-media:has(.media-card-image) {
    grid-template-columns: 1fr;
    max-width: min(100%, 720px);
    margin-inline: auto;
  }

  .comparison-media:has(.media-card-image) .media-card-video {
    max-width: min(100%, 330px);
  }

  .series-labels {
    gap: 0.2rem;
    font-size: 0.62rem;
  }
}

@media (max-width: 720px) {
  .page-shell {
    width: min(100% - 1rem, 1120px);
    padding-top: 1rem;
  }

  .hero {
    padding-top: 0.75rem;
  }

  .intro-panel,
  .dataset {
    padding: 1.15rem;
  }

  .dataset-nav {
    max-width: none;
  }

  .comparison-media {
    grid-template-columns: 1fr;
    max-width: none;
  }

  .comparison-media:has(.media-card-image) {
    grid-template-columns: 1fr;
    max-width: none;
  }

  .plot-embed iframe {
    height: 24rem;
  }
}